MELITTIN DERIVED PEPTIDE-DRUG CONJUGATE, M-DM1, INHIBITS TUMOR PROGRESSION AND INDUCES EFFECTOR CELL INFILTRATION IN MELANOMA BY TARGETING M2 TUMOR-ASSOCIATED MACROPHAGES

BackgroundMelanoma has the highest mortality rate among all the types of skin cancer.In melanoma, M2-like tumor-associated macrophages (TAMs) are associated with the invasiveness of tumor cells and a poor prognosis.Hence, the depletion or reduction of M2-TAMs is a therapeutic strategy for the inhibition of tumor progression.The aim of this study wa

This article highlights the role of social movements in environmental conservation by developing an ecovillage in Damaran Baru in Bener Meriah Regency, Aceh, Indonesia, focusing on ecological Zip Ties sustainability and gender inclusivity.The primary aim of this paper is to explore how community-based social movements and government policies can co

A large quantity of trace metals has been continuously polluting the environment as a result of increasing urbanization and industrial processes.In 2016-2017, the metal (Cd, Cu, Cr, Ni, Pb, and Zn) levels were determined in fecal pellets of Blue Rock Pigeon (Columba livia) at Bais Godam (industrial location) in Jaipur and Chittora (rural location)

Rosanna Dammacco,1 Giovanni Alessio,1 Ermete Giancipoli,2 Patrizia Leone,3 Anna Cirulli,3 Leonardo Resta,4 Angelo Vacca,3 Franco Dammacco3 1Department of Ophthalmology and Neuroscience, University of Bari “Aldo Moro”, Medical School, Bari, Italy; 2Department of Biomedical Sciences, Ophthalmology Unit, University of Sassari, Sassari, Ita

Abstract Background Initiation of ventilation using high tidal volumes in preterm lambs causes lung injury and inflammation.Antenatal corticosteroids mature the lungs of preterm infants and postnatal corticosteroids are used to treat bronchopulmonary dysplasia.Objective To test if antenatal or postnatal corticosteroids would decrease resuscitation